Seronegative patients vaccinated with cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation

Evidence against GB virus C infection in dromedary camels.

A recent publication described finding GB virus C (GBV-C) RNA in 4 of 22 dromedary camel sera, and sequence analysis found that these viruses were phylogenetically clustered within human GBV-C isolates. Since all other GB viruses to date form monophyletic groups according to their host species, the close relationship between the sequences generated from camel sera and human GBV-C isolates seeme...

A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant.

A phase I randomized, double-blind, placebo-controlled trial was done with a cytomegalovirus (CMV) vaccine based on the envelope glycoprotein, gB, combined with a novel adjuvant, MF59. Participants received CMV gB vaccine with MF59 or CMV gB with alum or placebo at 0, 1, and 6 months. A fourth vaccine was given at 12 months to a subgroup. Levels of neutralizing antibody and antibody to gB 2 wee...

1113Safety and Efficacy of a Cytomegalovirus Glycoprotein B (gB) Vaccine in Adolescent Girls

in Adolescent Girls David I. Bernstein, MD, MA; S. Todd Callahan; Flor Munoz-Rivas, MD; Rick Rupp, MD; Kathryn Edwards, MD, FIDSA; Lawrence R. Stanberry, MD, PhD; Sylvie Pichon; Cyrille Amegashie; Abbie R. Bellamy; Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH; Division of Adolescent and Young Adult Health, Vanderbilt, Nashville, TN; Baylor College of M...

Cellular and humoral immune responses to alphavirus replicon vaccines expressing cytomegalovirus pp65, IE1, and gB proteins.

Development of vaccines against cytomegalovirus (CMV) is an important public health priority. We used a propagation-defective, single-cycle RNA replicon vector system derived from an attenuated strain of an alphavirus, Venezuelan equine encephalitis virus, to produce virus-like replicon particles (VRP) expressing various combinations of pp65, IE1, or gB proteins of human CMV. Protein expression...

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